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Study on Preparation of Poly (Lactic-Co-Glycolic Acid) and Methods to Relieve Acid Accumulation in PLGA Degradation Process

Shanghui Sun, Yahui Zhou

1Chemist in Beloteca, Inc, San Diego, CA 92121, USA.

2No. 4 High school in Harbin, Heilongjiang, China.

*Corresponding author: Shanghui Sun

Published: 27 September 2022 How to cite this paper


In recent years, Poly (lactic-co-glycolic acid), PLGA, one of the biodegradable polyesters with favorable biocompatibility and biodegradability, has found a wide range of applications in the drug delivery system, tissue engineering scaffold, medical devices, and so forth. However, acid degradation products of PLGA, may accumulate around the tissue to give rise to the well-known aseptic inflammation phenomenon. In this study, the basic amino acid Lysine was introduced into the PLGA to alleviate acid accumulation and the study is mainly divided into four parts. Preparation of PLGA and PLGA/Lysine composite nanofibers through electro-spinning; Lysine release behaviour of the PLGA-based composite nanofibers; in vitro degradation experiments of the PLGA and PLGA/Lysine nanofiber mats, and cell culture of vascular smooth cells with degradable fluid to evaluate cytotoxicity. Observing the morphology of composite nanofibers in each part of the study using SEM indicates that the addition of Lysine is capable of neutralizing PLGA acid product generated in the procedure of degradation.

KEYWORDS: PLGA, Biocompatibility, Composite Nanofibers, Electro-Spinning, Biodegradation


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How to cite this paper

Shanghui Sun, Yahui Zhou. Study on Preparation of Poly (Lactic-Co-Glycolic Acid) and Methods to Relieve Acid Accumulation in PLGA Degradation Process. OA Journal of Chemistry and Materials, 2022, 1(1), 16-21.

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